What is FamilialAdenomatous Polyposis?
Familial Adenomatous Polyposis is a genetic condition. It is diagnosed when a person develops more than 100 adenomatous colon polyps. An adenomatous polyp is an area where normal cells that line the inside of a person’s colon form a mass on the inside of the intestinal tract. On average, polyps develop in people with FAP is in their mid-teens. Most people with FAP will have multiple colon polyps by age 35. If FAP is not recognized and treated, there is a very high likelihood that a person will develop colorectal cancer.
Individuals with FAP also have an increased chance of developing cancer in other organs, including the stomach, small intestine, and pancreas, and biliary tree. The risk for hepatoblastoma, a type of liver cancer, is increased in children with FAP. Desmoid tumors/desmoid fibromatosis, a locally aggressive tumor that does not spread (metastasize), and a type of brain tumor called medulloblastoma can also occur in some individuals. The risk for papillary thyroid cancer is also increased, Familial Adenomatous Polyposis Market
What are all symptoms of Familial Adenomatous Polyposis?
Not all symptoms of FAP are cancer-related. Some additional features of FAP may include: osteomas (noncancerous bony growths, usually found on the jaw), extra, missing, or unerupted teeth, congenital hypertrophy of the retinal pigment epithelium (CHRPE), which is an eye condition that is present at birth that does not affect vision, but it is a condition that an eye the physician may see during an examination with a special instrument called an ophthalmoscope. Benign (noncancerous) skin changes, such as epidermoid cysts and fibromas and adrenal masses are also typical symptoms of FAP.
What are the FamilialAdenomatous Polyposis Market Report Types?
There are four subtypes of familial adenomatous polyposis, namely, Classic familial adenomatous polyposis, Attenuated familial adenomatous polyposis (AFAP), Gardner syndrome, and Turcot syndrome.
Familial adenomatous polyposis is caused by changes in a gene known as APC. About 20% to 25% of people with FAP have a new APC mutation that did not come from a parent. People with AFAP have fewer polyps in the large and small intestines, usually no more than 30 by the time they are adults while people with Classic familial adenomatous polyposis, Gardner syndrome and Turcot the syndrome usually develop at least 100 polyps, but usually many more, in the large and small intestines by the time they are adults.
Most participants who went under surgery for the treatment of FAP expressed unmet needs, such as lack of healthcare providers with good knowledge about FAP, practical and psychosocial support, FAP educational programs, and organized meetings with other persons with the condition.
Most patients are asymptomatic for years until the adenomas are large and numerous, and cause rectal bleeding or even anemia, or cancer develops. Without surgical intervention, FAP patients are nearly at a 100% risk of developing colorectal cancer by the age of 45.
Original Source:- Familial Adenomatous Polyposis Market Research
